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Platelets activation and adhesion on TiN+Ti2N+αTi(N) layer produced in plasma space on Ti6Al4V alloy

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The original extracorporeal pulsatile heart support device, called POLVAD, has been developed in Poland. It was used in over 200 patients with the longest duration of 1 year. The innovative tilting disc valve for this device is developing. The valve consists of original valve ring, free of pivot element crossing the blood stream (Fig. 1). The valve ring is made of titanium alloy Ti6Al4V type. Titanium and its’ alloys demonstrate numbers of beneficial properties in medical applications. They are a subject to study metallosis, they demonstrate very good biotolerance to tissue habitat, high resistance to corrosion, and thermodynamical stability in physiological conditions. The thromobogenicity is one among t he problems, regarding titanium and its’ alloys applications as the biomaterials. For that reasons appropriate surface modifying layers of titanium are developed - to improve material properties for blood contact. Nowadays, surface engineering techniques are used as base point for creation a proper chemical composition, structure and physicochemical status of biomaterial surfaces - to obtain its required biological properties and functions. The surface modifications of titanium and its’ alloys influence surface layer structure and morphology, adhesion and inside layer residual stress. They influence a total implant stability in live organism habitat as well as improve biocompatibility. The microstructure, roughness and thrombogenicity of diffusive titanium nitride layers on titanium Ti6A14Al alloy are examined in the work - together with thrombogenicity testing, performing as the material induced platelets activation and its adhesion to the biomaterial surface. MATERIAL AND METHODS The titanium nitride layers were formed at the Surface Engineering Department of Warsaw University of Technology. Three diffusive layers: TiN+Ti2N+αTi(N), TiO2+Ti2N+αTi(N), and Ti(OCN[...]

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