Wyniki 1-1 spośród 1 dla zapytania: authorDesc:"Lorenzo FASSINA"

Automated optimal design of wells for electromagnetic cell stimulation DOI:10.15199/48.2019.05.01

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In the last decades, the electromagnetic stimulation in vitro and in vivo has become a promising research field because it allows to modulate the behaviour of cells and tissues. In particular, when the cells are exposed to a timevarying magnetic field, an electric field is induced and thus a current density arises, because the cell culture medium is conductive. The interaction between the induced current density and the time-varying magnetic field gives rise to mechanical stress acting on the cells [1]. In this paper, new kind of wells for obtaining a homogeneous stress and stimulation of a considerable large amount of cells are designed [2]. This design problem is formulated as a multiobjective one and its solution is found by means of the Biogeography-Inspired Multi-objective Optimization algorithms, BiMO [3,4] and the μ-BiMO algorithms [5]. These methods have shown to be successful for various applications [6-10]. In particular, when the forward problem requires a high computational time e.g. when Finite Element FE simulations are used, the μ-BiMO algorithm gave good results. In general, the aim of this study has been to design different optimally-shaped wells for electromagnetic stimulation of cells [11-15]. The forward problem The electromagnetic stimulation of cells is done by means of the so-called “electromagnetic bioreactor" (Fig. 1), which is a device based on two solenoids connected in series and powered by a pulse generator (Igea, Carpi, Italy) at 75 Hz [11]. In order to simulate the electric E and magnetic B fields in the bioreactor, a 3D time-dependent finite-element model was implemented in MagNet, a commercial code by Mentor-Infolytica. Fig.1. Electromagnetic bioreactor Fig.2. Magnetic induction field [T] distribution in the middle of the bioreactor In the conductive regions, the electromagnetic problem is solved in terms of the phasors of the electric vector potential T and the scalar ma[...]

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